♦ Sesame and its health benefits as evidenced by numerous studies.
Sesame has traditionally used been used for its excellent health benefits; prophylactic, therapeutic and cosmetic!
• Amongst the multiple benefits it has traditionally been used to:
Aid wound healing and avoid scar tissue, alleviate and treat arthritis and arthritic pain, treat itchy scalp, dry hair and improve hair health and give it more luster and shine.
It has been used as a sunscreen, as an anti-aging anti-cancer agent, treat diabetes and improve overall health due to its potent antioxidant and anti-inflammatory properties.
♦ Scientific studies confirming the efficacy of Sesame for various conditions:
Please note that this is a small selection of studies, for every study cited there are many more confirming the same or similar outcomes.
- Ageing, prevention & slowing 
- Atherosclerosis 
- Cardiovascular Disease 
- Diabetes 
- Fatigue 
- Heart Attack / Mocardial Infarction 
- Heart Disease 
- Hypertension 
- Hypercholesterolemia 
- Infant growth, health & sleep 
- Insomnia 
- Kidney Disease 
- Liver Disease 
- Neuro-degenerative Disease 
- Osteoarthritis 
- Parkinsons Disease 
- Wound Healing 
|Nutrient||content||% of RDA|
|Vitamin B6||0.2 mg||11%|
♦ Sesame Oil also contains the following nutrients and 'active' ingredients:
- Oleic acid
- Palmitic acid
- Stearic acid
- Linoleic acid
-  A blend of sesame oil and rice bran oil lowers blood pressure and improves the lipid profile in mild-to-moderate hypertensive patients.
Sesame oil and rice bran oil are known for their unsaturated fatty acids and antioxidants contents and have been reported to reduce the cardiovascular risk.
Significant reduction in blood pressure (systolic, diastolic, and mean arterial) from days 0 to 15, 30, 45, and 60 were observed in hypertensives treated with sesame oil blend alone (P < .001), nifedipine alone (P < .001), and combination of sesame oil blend and nifedipine (P < .001).
We demonstrate for the first time that using a blend of sesame oil and rice bran oil as cooking oil showed a significant antihypertensive and lipid-lowering action and had noteworthy additive effect with antihypertensive medication.
J Clin Lipidol. 2016 Mar-Apr;10(2):339-49. Epub 2015 Dec 24. PMID: 27055965
-  The Effects of Sesame Consumption on Glycemic Control in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trial.
In recent years, diabetes has become a global health problem that creates a tremendous economic burden for many countries.
A total of 605 studies were identified through online searching, and a total of eight RCTs representing 382 participants were included in this study.
The meta-analyses revealed that sesame consumption significantly decreases serum fasting blood sugar (FBS):
(WMD: -28.23 mg/dl; 95% CI (-39.16, -17.13), = 97.6%; 95% CI (96, 98)), and hemoglobin A1c (HbA1c): (WMD: -1.00%; 95% CI (-1.11, -0.88), = 0%; 95% CI (0, 79)) as compared to the control group.
This study provides evidence of the hypoglycemic effects of sesame consumption, particularly in diabetic patients.
Additional RCTs on sesame and its preparations should be conducted in different populations to increase generalizability.
Evid Based Complement Alternat Med. 2021 ;2021:2873534. Epub 2021 Oct 18. PMID: 34707665
-  Effects of massage & use of oil on growth, blood flow & sleep pattern in infants.
Full term born healthy infants (n = 125), 6 +/- 1 wk of age, wt > 3000 g were randomly divided into five groups.
Infants received (i) herbal oil, (ii) sesame oil, (iii) mustard oil, or (iv) mineral oil for massage daily for 4 wk. The fifth group did not receive massage and served as control.
Massage improved the weight, length, and midarm and midleg circumferences as compared to infants without massage.
However, in the group with sesame oil massage, increase in length, midarm and midleg circumferences by 1.0, 0.9 and 0.7 cm, respectively was significant (P < 0.05, < 0.01 & < 0.05).
The femoral artery blood velocity, diameter and flow improved significantly by 12.6 cm/sec, 0.6 cm and 3.55 cm3/sec respectively in the group with sesame oil massage as compared to the control group. Massage improved the post massage sleep, the maximum being 1.62 h in the sesame oil group (P < 0.0001).
INTERPRETATION & CONCLUSIONS:
Massage in infancy improves growth and post-massage sleep.
However, only sesame oil showed significant benefit.
Indian J Med Res. 2000 Dec;112:212-7. PMID: 11247199
-  Two Blends of Refined Rice Bran, Flaxseed, and Sesame Seed Oils Affect the Blood Lipid Profile of Chinese Adults with Borderline Hypercholesterolemia to a Similar Extent as Refined Olive Oil.
Individual vegetable oils have a characteristic fatty acids (FA) composition and unique phytonutrient profiles, enabling formulation of oil blends that may have health-promoting effects.
Compared with baseline (week 0), there were significant reductions during the post-intervention time points in serum total cholesterol (-3.47%; P < 0.0001), LDL cholesterol (-4.16%; P < 0.0001), triglycerides (-10.3%; P < 0.0001), apoB (-3.93%; P < 0.0001), total to HDL-cholesterol (-3.44%; P < 0.0001) and apoB to apoA1 (-3.99%; P < 0.0001) ratios, systolic and diastolic blood pressures (-3.32% and -3.16%, respectively; both P < 0.0001), and serum glucose (-1.51%; P < 0.05) and a small but significant increase in body weight (+0.7%; P < 0.001) for all 3 intervention oils
Using blended vegetable oils that are extensively consumed in Asia, this study found that specific oil blends can improve blood lipid profile and other cardiometabolic parameters, to a similar extent as refined olive oil, in Chinese adults with borderline hypercholesterolemia.
J Nutr. 2020 Dec 10 ;150(12):3141-3151. PMID: 33188423
-  Effects of Ayurvedic Oil-Dripping Treatment with Sesame Oil vs. with Warm Water on Sleep: A Randomized Single-Blinded Crossover Pilot Study.
Ayurvedic oil-dripping treatment (Shirodhara) is often used for treating sleep problems.
SOS (sesame oil Shirodhara) improved sleep quality, as measured by PSQI.
The SOS score was 1.83 points lower (95% confidence interval [CI], -3.37 to -0.30) at 2-week follow-up and 1.73 points lower (95% CI, -3.84 to 0.38) than WWS at 6-week follow-up.
This pilot study demonstrated that SOS may be a safe potential treatment to improve sleep quality and QOL in persons with sleep problems.
J Altern Complement Med. 2016 Jan ;22(1):52-8. Epub 2015 Dec 15. PMID: 26669255
-  Effects of sesame seed supplementation on inflammatory factors and oxidative stress biomarkers in patients with knee osteoarthritis.
Fifty patients with knee OA (Osteoarthritis) were allocated into two groups namely control and sesame group.
25 patients in the control group received 40 g placebo powder per day while 25 patients in the sesame group received 40 g of sesame seed daily during two months of study along with standard medical therapy.
In the sesame group, a significant decrease in serum MDA and hs-CRP were seen after two months of study (P<0.05).
There was a significant difference in mean serum IL-6 between two groups after treatment (P=0.001).
Sesame seed is a natural and safe substance that may have beneficial effects in patients with knee OA, and it may provide new complementary and adjunctive treatment in these patients.
Acta Med Iran. 2015 ;53(4):207-13. PMID: 25871017
-  Ardeh (Sesamum indicum) Could Improve Serum Triglycerides and Atherogenic Lipid Parameters in Type 2 Diabetic Patients: A Randomized Clinical Trial.
Data suggest that sesame seeds have properties beneficial to modulating lipid disorders and decreasing cardiovascular disease (CVD) risk factors.
This randomized clinical trial included 41 patients with type 2 diabetes, who were randomly assigned to one of the two groups: group A (Ardeh 28 g/d, n = 21) and group B (control, n = 20).
After an initial two-week washout period, the patients in group A, replaced a part of their usual breakfast with two tablespoon (tbsp) (~ 28 g) Ardeh, while group B patients continued the usual breakfast meal for six weeks; energy content of both breakfast meals was maintained in the same range.
After six weeks, there were significant decreases in serum TG (15.3 mg/dL) and AIP (39 %) in group A.
Moreover, slight decreases in serum TC, LDL-C, and other atherogenic lipid parameters and a mild increase in HDL-C also were observed during Ardeh supplementation.
Ardeh could have favorable effects in decreasing CVD risk factors in type 2 diabetics.
-  Evaluation on the combined effect of Sesamin and Schisandra extract on blood fluidity.
Several studies have demonstrated a link between blood viscosity and various forms of liver dysfunction.
Therefore, we investigated the effect of liver protective herbal materials, Sesamin combined with extract of Schisandra chinensis berry (Schisandra) for its potential to improve blood fluidity in humans.
No safety concern and adverse effects were observed during the 2-week continuous intake period.
Intake of SCH reduced blood passage time by 9.0% and 9.7% at 1 and 2 weeks, respectively.
In conclusion, this pilot clinical study indicates that the combined administration of sesamin with schisandra extract could improve blood fluidity after 1 week of oral intake and this effect was sustained up to 2 weeks.
Bioinformation. 2008 Jan 27;2(6):249-52. PMID: 18317575
-  Effect of Sesamin Supplementation on Cardiovascular Risk Factors in Women with Rheumatoid Arthritis.
Rheumatoid arthritis (RA) is an inflammatory disease with increased mortality from cardiovascular disease (CVD).
Oxidative stress has a critical role in the pathogenesis of RA and CVD.
Sesamin, the main lignin constituent of sesame, has several antioxidant and anti-inflammatory effects.
This study aimed to investigate the effects of sesamin supplementation on anthropometric indices, lipid profile, blood pressure, and oxidative stress markers in women with RA.
At the end of study, sesamin supplementation significantly decreased serum levels of MDA (p = 0.018) and increased TAC and high-density lipoprotein cholesterol (HDL-C) ('good' cholesterol) levels in patients with RA (p = 0.020 and p = 0.007, respectively).
In the sesamin group, the mean of weight, body mass index, waist-to-hip ratio, body fat, systolic blood pressure, and the concentration of other lipid profiles (triglycerides, total cholesterol, and low-density lipoprotein cholesterol [LDL-C]) were also significantly decreased at the end of study compared to baseline values (p<0.05).
Sesamin exhibited a protective effect on cardiovascular risk factors in patients with RA.
J Am Coll Nutr. 2016 May-Jun;35(4):300-7. Epub 2015 Jul 7. PMID: 26151734
-  Tahini consumption affects blood pressure and endothelial function in healthy males.
Sesame (Sesamum indicum L.) is rich in polyunsaturated fatty acids, proteins, vitamin E, and lignans. Recent studies have highlighted the antioxidant, antihypertensive, hypolipidemic, and appetite-control properties of sesame seeds and sesame oil.
Twenty healthy men with mean age of 28 y and mean BMI of 25.81 kg/m were included. After a 12-h fast, baseline blood was collected, participants consumed 50 g of tahini, and blood collection was repeated 4 h postprandially.
Assessment of blood pressure, pulse rate, hemodynamic parameters, and endothelial function was performed at baseline and at the end of the trial.
A statistically significant decrease in diastolic blood pressure (p = 0.010) and pulse rate (p = 0.002) was observed 4 h after tahini consumption.
Significant increases in serum triglycerides (p < 0.001) and flow-mediated dilatation were observed (p = 0.022) 4 h postprandially.
This is the first study to report that tahini consumption can lower blood pressure and pulse rate and improve endothelial function, suggesting a healthy snack in place of others with a less desirable lipid profile.
J Hum Hypertens. 2021 Oct 27. Epub 2021 Oct 27. PMID: 34707227
-  A pilot study of open label sesame oil in hypertensive diabetics.
The objective of this study was to investigate the effect of sesame oil in hypertensive diabetics medicated with atenolol (beta-blocker) and glibenclamide (sulfonylurea).
Systolic and diastolic BP decreased remarkably.
When oil substitution was withdrawn, BP values rose again.
Body weight, body mass index, girth of waist, girth of hip, and waist: hip ratio were reduced upon substitution of sesame oil.
Plasma glucose, HbA1c, TC, LDL-C, and TG were decreased.
TBARS level was reduced, while the activities of enzymic and the levels of nonenzymic antioxidants were increased.
Plasma sodium levels were reduced, while potassium levels were elevated.
These results indicate that substitution of sesame oil as the sole edible oil has an additive effect in further lowering BP and plasma glucose in hypertensive diabetics.
J Med Food. 2006 Fall;9(3):408-12. PMID:17004907
-  The efficacy of topical sesame oil in patients with knee osteoarthritis: A randomized double-blinded active-controlled non-inferiority clinical trial.
Sesame oil is an herbal product that has been used to treat the joints pain in several traditional medicines.
In this study, we evaluated the efficacy of topical sesame oil versus diclofenac gel in patients with knee osteoarthritis (OA).
At the follow-up visits, sesame oil was not inferior to diclofenac regarding scores of WOMAC pain, 8-meter walk test, and knee flexion angle.
It seems that the topical sesame oil was non-inferior to diclofenac gel (topical analgesic) on the reduction of the knee OA pain and improvement of some indicators of its function.
Complement Ther Med. 2019 Dec ;47:102183. Epub 2019 Aug 22. PMID: 31780006
-  Anti-atherosclerotic and anti-inflammatory actions of sesame oil.
Atherosclerosis, a major form of cardiovascular disease, has now been recognized as a chronic inflammatory disease.
Nonpharmacological means of treating chronic diseases have gained attention recently. We previously reported that sesame oil has anti-atherosclerotic properties.
The sesame oil diet significantly reduced atherosclerotic lesions, plasma cholesterol, triglyceride, and LDL cholesterol levels in LDLR(-/-) mice.
Plasma inflammatory cytokines, such as MCP-1, RANTES, IL-1α, IL-6, and CXCL-16, were significantly reduced, demonstrating an anti-inflammatory property of sesame oil.
Gene array analysis showed that sesame oil induced many genes, including ABCA1, ABCA2, APOE, LCAT, and CYP7A1, which are involved in cholesterol metabolism and reverse cholesterol transport.
In conclusion, our studies suggest that a sesame oil-enriched diet could be an effective nonpharmacological treatment for atherosclerosis by controlling inflammation and regulating lipid metabolism.
J Med Food. 2015 Jan ;18(1):11-20. PMID: 25562618
-  Sesamin attenuates intercellular cell adhesion molecule-1 expression in vitro in TNF-alpha-treated human aortic endothelial cells and in vivo in apolipoprotein-E-deficient mice.
Sesame lignans have antioxidative and anti-inflammatory properties.
We focused on the effects of the lignans sesamin and sesamol on the expression of endothelial-leukocyte adhesion molecules in tumor necrosis factor-alpha (TNF-alpha)-treated human aortic endothelial cells (HAECs).
When HAECs were pretreated with sesamin (10 or 100 microM), the TNF-alpha-induced expression of intercellular cell adhesion molecule-1 (ICAM-1) was significantly reduced (35 or 70% decrease, respectively) by Western blotting.
These results also suggest that sesamin may prevent the development of atherosclerosis and inflammatory responses.
Mol Nutr Food Res. 2010 Sep ;54(9):1340-50. PMID: 20306475
-  Sesame Lignans and Vitamin E Supplementation Improve Subjective Statuses and Anti-Oxidative Capacity in Healthy Humans With Feelings of Daily Fatigue
For the first time, we demonstrated that the supplementation of sesame lignans (sesamin/episesamin = 1/1) with VE could significantly improve subjective fatigue-related status and anti-oxidative capacity particularly in middle-aged and elderly people experiencing feelings of daily fatigue.
These results suggest that sesame lignans with VE supplementation is safe and useful for alleviating daily fatigue and oxidative stress.
Sesamin has anti-oxidative functions in vivo.
Fatigue is caused in part by oxidative stress.
We evaluated whether sesame lignans (sesamin/episesamin = 1/1, 10 mg) with vitamin E (55 mg of α-tocopherol) (SVE) could improve subjective statuses and anti-oxidative capacity in humans using questionnaires on fatigue, sleep and physical appearance, as well as low-density lipoprotein oxidation lag time.
PMCID: PMC4803842 PMID: 26153159
-  Normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats.
The seeds of Sesamum indicum Linn. (Pedaliaceae) has been used traditionally for the treatment of wounds in Buldhana district of Maharashtra state.
Sesamol is the main anti-oxidative constituent contained mainly in the processed sesame seed oil which has not been explored scientifically for its wound healing activity.
The tensile strength significantly (p<0.05) increased with SM at 471.40±14.66 g when compared to control at 300.60±9.16 g in normal and DM suppressed healing.
These results indicate that sesamol could be a promising drug in normal as well as delayed wound healing processes.
J Ethnopharmacol. 2011 Jan 27 ;133(2):608-12. Epub 2010 Oct 28. PMID: 21035533
-  Sesaminol prevents Parkinson's disease by activating the Nrf2-ARE signaling pathway.
Parkinson's disease (PD) is a neurodegenerative disease caused by the degeneration of substantia nigra neurons due to oxidative stress.
Sesaminol has strong antioxidant and anti-cancer effects.
The sesaminol group showed strong expression of Nrf2 in the cytoplasm and nucleus. NAD(P)H: quinone oxidoreductase (NQO1) activity was enhanced in the 6-OHDA group and further enhanced in the sesaminol group.
Furthermore, the neurotoxine rotenone was orally administrated to mice to prepare anPD model.
The motor function of rotenone-treated mice was shorter than that of the control group, but a small amount of sesaminol restored it to the control level
These results suggest that sesaminol has a preventative effect on PD.
Heliyon. 2020 Nov ;6(11):e05342. Epub 2020 Nov 2. PMID: 33163674
-  The prophylactic protective effect of sesamol against ferric-nitrilotriacetate-induced acute renal injury in mice.
The aim of this study was to examine the prophylactic protective effects of 3,4-methylenedioxyphenol (sesamol) on ferric-nitrilotriacetate (Fe-NTA)-induced acute renal damage in mice
Sesamol inhibited Fe-NTA-induced acute renal injury, renal lipid peroxidation, the levels of renal hydroxyl radical and superoxide anion generated, and the activity of xanthine oxidase in mice.
Therefore, we concluded that sesamol protected mice against Fe-NTA-induced oxidative-stress-associated acute renal injury by at least partially inhibiting the production of reactive oxygen species.
Food Chem Toxicol. 2008 Aug ;46(8):2736-41. Epub 2008 Apr 29. PMID: 18539378
-  Protective effects of sesamol and its related compounds on carbon tetrachloride induced liver injury in rats.
Sesamol is a kind of antioxidant and exists in sesame oil.
This paper describes the protective effect of sesamol against carbon tetrachloride (CCl4)-induced liver injury in rats.
Consequently, significant protective effects were found in methylenedioxybenzene, isosafrole, safrole, methylenedioxyaniline and methylenedioxyacetophenone.
These five compounds had a methylenedioxy group had protective effects, it was considered that the protective effects of the methylenedioxy group were influenced by substituent groups on 4 position of methylenedioxy phenyl compounds.
In addition, sesamol, methylenedioxybenzene and isosafrole showed significant protective effects against cholestasis induced by CCl4.
Yakugaku Zasshi. 1994 Nov ;114(11):901-10. PMID: 7853152
-  Protective effect of sesamol against 3-nitropropionic acid-induced cognitive dysfunction and altered glutathione redox balance in rats.
Sesamol (SML) (Sesamum indicum, Linn, Pedaliaceae) has been used traditionally as a health supplement in India and other countries for a long time. It is a well-known antioxidant, currently being tried against several neurological disorders.
The present study was designed to evaluate the potential of sesamol treatment against 3-nitropropionic acid (3-NP)-induced cognitive impairment and oxidative damage in striatal, cortex and hippocampal regions of the rat.
Sesamol pre-treatment restored oxidative defence possibly by its free radical scavenging activity as compared to the 3NP-treated group.
The present study suggests that sesamol could be used as an effective agent in the management of Huntington's disease (neurodegenerative disease).
Basic Clin Pharmacol Toxicol. 2010 Jul ;107(1):577-82. Epub 2010 Jan 25. PMID: 20102363
-  Protective effect of sesamol against myocardial infarction (heart attack) caused by isoproterenol in Wistar rats.
This study was designed to investigate the cardioprotective effect of sesamol on isoproterenol (ISO)-induced myocardial infarction in adult male albino Wistar rats.
…. Administration of sesamol at different doses 50, 100 and 200 mg/kg body weight intraperitoneally for 7 days prevented the above changes and improved towards normality; the 50 mg dose was more effective than the other two doses.
Redox Rep. 2010 ;15(1):36-42. PMID: 20196927
-  Sesamol, a lignan in sesame, possesses several bioactivities, such as antioxidation, anti-inflammation, and neuroprotective capability. In this study, the effects of sesamol on aging-caused cognitive defects are investigated.
Behavioral tests revealed that sesamol improved aging-associated cognitive impairments.
Sesamol decreased aging-induced oxidative stress via suppression of malondialdehyde production and increased antioxidant enzymes.
Histological staining showed that sesamol treatment improved aging-induced neuronal damage and synaptic dysfunction in hippocampus.
Furthermore, sesamol significantly reduced aging-induced neuroinflammation by inhibiting the microglial overactivation and inflammatory cytokine expressions.
Meanwhile, the accumulation of Aβ was reduced by sesamol treatment.
Moreover, sesamol protected the gut barrier integrity and reduced LPS release, which was highly associated with its beneficial effects on behavioral and inflammatory changes.
In conclusion, our findings indicated that the use of sesamol is feasible in the treatment of aging-related diseases
J Agric Food Chem. 2020 Feb 18. Epub 2020 Feb 18. PMID: 32067456
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